The Russians beat Real Madrid 1-0 in their first meeting after a game in which the Spanish side hit the woodwork on four occasions and spurned a host of chances, but have otherwise disappointed in the tournament.
Real Madrid coach Santiago Solari is likely to make squad rotations with players such as Keylor Navas, Isco, Marco Asensio and Dani Ceballos all given starts ahead of their weekend game at home to struggling Rayo Vallecano
Valencia are also in action on Wednesday as they host Manchester United at a moment when neither side are at their best in domestic competitions.
The game has nothing at stake after Marouane Felaini’s controversial late winner against Young Boys in the last round of matches assured Manchester United would finish second in the group, while also making it impossible for the Swiss side to catch Valencia in third place.
United travel to Spain after a 4-1 win over bottom of the table Fulham at the weekend, but with coach Jose Mourinho still being questioned in the press.